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Bax, Par-6 and aPKC is not required for axon and dendrite specification

Overexpression of Baz or Par-6, aPKC does not have any effect on axon morphology or number in Drosophila melanogaster (fruit fly). New study shown by Melissa M Rolls from penn state and Chris Q Doe from univ of oregon.

Dec 24, 2011

Role of Fibroblast growth factor (FGF) in neural stem cell growth

Fibroblast growth factor (FGF) constitutes a large family of polypeptide growth factors found in a variety of multicellular organisms, including invertebrates. The function of FGFs is not restricted to cell growth. Instead, FGFs are involved in diverse cellular processes including chemotaxis, cell migration, differentiation, cell survival, and apoptosis. The common feature of FGFs is that they are structurally related and generally signal through receptor tyrosine kinases. FGFs play an important role in embryonic development in invertebrates and vertebrates. The human FGF protein family consists of 22 members that share a high affinity...

Dec 3, 2011

Hedgehog protein – signaling pathway in vertebrate neural development

Hedgehog family of proteins is signaling proteins which control the cell growth, survival, fate and pattern (almost every aspect) of the vertebrate body plan.  The name was derived from the short and spiked phenotype of the cuticle of the Hh mutant Drosophila larvae. Except in C.elegans, It is found in both vertebrates and invertebrates. In C.elegans, it has several proteins homologous to the Hh receptor Ptc.   There are three subgroups in hedgehog protein family:                     A.  Desert hedgehog (Dhh)                  ...

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